For three years, as part of the anonymous relocation of the former 'Quantico team', Alex enjoyed a simple family life in Tuscany (Italy) with wine grower Luciano and his doting daughter Isabella. Now killers suddenly appear in the night, which she can overpower, but it's time to move on. Picking up her emergency stash in a Swiss bank, she bumps into Ryan, whom she left clueless, finding he happily married Shelby. Both ex-lovers accept a call to return to New York, where Shelby was kidnapped by arms dealer 'the Widow', who demands for her liberation a terrible weapon. A team is(re)assembled, including CIA-promoted Owen and Harry, who dumps his bizarre job as overqualified minder of the crazy brother of British contraband tycoon Pillay, in whose name their undercover will bid at the widow' auction, Will is found on her team.